The purpose of this work was to compare containment efficiency in a properly designed anteroom-equipped hospital AIIR at differential pressures ranging from 2.5 to 20 Pa under conditions of no provider traffic and simulated high provider traffic.įluorescent microspheres were released into the AIIR to simulate infectious droplet nuclei. Current US design standards require a pressure differential of only 2.5 Pascals (Pa), compared with 15 Pa in some other countries. Airborne infectious isolation rooms (AIIRs) are maintained at a negative pressure relative to surrounding areas to prevent migration of potentially infectious droplet nuclei.